General Information

  • ID:  hor004207
  • Uniprot ID:  P20757
  • Protein name:  Angiotensin-3
  • Gene name:  AGT
  • Organism:  Ovis aries (Sheep)
  • Family:  Serpin family
  • Source:  animal
  • Expression:  Expressed by the liver and secreted in plasma.
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Ovis (genus), Caprinae (subfamily), Bovidae (family), Pecora (infraorder), Ruminantia (suborder), Artiodactyla (order), Laurasiatheria (superorder), Boreoeutheria, Eutheria, Theria, Mammalia (class), Amniota, Tetrapoda, Dipnotetrapodomorpha, Sarcopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  GO:0004867 serine-type endopeptidase inhibitor activity
  • GO BP:  GO:0003081 regulation of systemic arterial blood pressure by renin-angiotensin; GO:0010718 positive regulation of epithelial to mesenchymal transition; GO:0042310 vasoconstriction; GO:0097746 blood vessel diameter maintenance; GO:1901394 positive regulation of transforming growth factor beta1 activation
  • GO CC:  GO:0005576 extracellular region; GO:0005615 extracellular space

Sequence Information

  • Sequence:  RVYIHPF
  • Length:  7
  • Propeptide:  MAPAGLSLGATILCLLAWAGLAAGDRVYIHPFHLLVHSKSNCDQLEKPSVETPADPTLTPVPIQTKSSPVDEEALWEQLVRATEKLEAEDRLRASEVGLLLNFMGFHVYKTLSETWSVASGLVFSPVALFSTLTSFYTGALDPTASRLQAFLGVPGEGQGCTSRLDGRKVLSSLQTIQGLLVAPGGASSQARLLLSTVVGLFTAPGLHLKQPFVQGLSSFAPITLPRSLDLSTDPNLAAEKINRFMHSATGWNMGRPLAAASPDSTLLFNAYVHFQGKMKGFSLLPGLTEFWVDNTTSVPVPMLSGSGTFHYWSDNQNHLSMTRVPLSANGYLLLIQPHHTLDLRKVEALIFQHNFLTRMKNLSPRAIHLTVPQLTLKASYDLQDLLAQAKLPTLLGAEANLGKISDANLRVGKVLNSVLFELKADGEQAPESVPQPAGPEALEVTLNSPFLLAVLERSSGALHFLGRVSRPLSAE
  • Signal peptide:  MAPAGLSLGATILCLLAWAGLAAG
  • Modification:  NA
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Stimulates aldosterone release.
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  AGTR2
  • Target Unid:  Q28929
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  AF-P20757-F1(AlphaFold_DB_ID)

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor004207_AF2.pdbhor004207_ESM.pdb

Physical Information

Mass: 103830 Formula: C46H66N12O9
Absent amino acids: ACDEGKLMNQSTW Common amino acids: FHIPRVY
pI: 9.35 Basic residues: 2
Polar residues: 1 Hydrophobic residues: 3
Hydrophobicity: 12.86 Boman Index: -778
Half-Life: 1 hour Half-Life Yeast: 2 min
Half-Life E.Coli: 2 min Aliphatic Index 97.14
Instability Index: 3882.86 Extinction Coefficient cystines: 1490
Absorbance 280nm: 248.33

Literature

  • PubMed ID:  3081342
  • Title:  Purification and Characterization of Ovine Angiotensinogen